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The stimulating effect of complete Freund's adjuvant on tumour induction by polyoma virus in mice and By Rous sarcoma virus in rats

✍ Scribed by V. S. Ter-Grigorov; I. S. Irlin


Publisher
John Wiley and Sons
Year
1968
Tongue
French
Weight
401 KB
Volume
3
Category
Article
ISSN
0020-7136

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✦ Synopsis


Complete Freund's adjuvant was shown to greatly stimulate viral oncogenesis both in the case of polyoma virus in niico and in the case q f Rous sarcoma virus in rats. Tumours appeared in 74 of CCS7BRIMv mice inkcred when newborn with polyoma virusadjuvant emulsion, whereas control rxiciJ injectpd with virus alone failed to develop turnours. Rous virus (Carr-Zilber strain) arid adjuvant when administered together as emulsions to Wistar rats (newborn or sucklings as wc4l as 2.5-month-old animals) resulted in a 100 7; tuniour incidence. I n control animals treated with the virus alone