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Induction of the ATP-sensitive potassium (uKATP-1) channel by endotoxemia

✍ Scribed by G. Czaika; Y. Gingras; E. Zhu; A.S. Comtois

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 208 KB
Volume: 23
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(200006)23:6<967::aid-mus19>3.0.co;2-p

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✦ Synopsis

The effect of sepsis on the ubiquitously expressed ATPsensitive potassium (uK ATP -1) channel expression was measured in Sprague-Dawley rat diaphragms. Rats were treated with either 0.5 ml saline or 20 mg/Kg E. coli lipopolysaccharides and sacrificed at 3, 6, 12, 24, or 48 h later. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis showed that channel mRNA expression was increased at 3 h and continued to rise up to 48 h. Western blotting analysis showed a ∼9-fold increase in channel protein expression 24 h after sepsis. Our results demonstrate that sepsis upregulates the uK ATP -1 channel.

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