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Induction of the acrosome reaction in guinea pig spermatozoa by calmodulin antagonist W-7

โœ Scribed by Nagae, T. ;Srivastava, P. N.

Book ID
111663158
Publisher
Wiley (John Wiley & Sons)
Year
1986
Weight
747 KB
Volume
14
Category
Article
ISSN
0148-7280

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Inhibition of the acrosome reaction of sea urchin spermatozoa by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)
โœ Sano, Kiyoshi ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 245 KB

A calmodulin antagonist, W-7 (N-(6-aminohexyl)-5-chloro-l-naphthalenesulfonamide), inhibited induction of the acrosome reaction of sea urchin spermatozoa by egg jelly at 20-50 pM, but W-5 did not. The latter, a chlorine-deficient derivative of W-7, has a lower affinity for calmodulin than does W-7.