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Induction of sister-chromatid exchanges (SCEs) by 5-fluorodeoxyuridine The role of 5-bromodeoxyuridine incorporated into parental DNA

✍ Scribed by P. Escalza; F. Cortés; J.B. Schvartzman

Book ID
113192922
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
415 KB
Volume
151
Category
Article
ISSN
0027-5107

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✍ William F. Morgan; Sheldon Wolff 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 492 KB

The fluorescence-plus-Giemsa (FPG) technique for analysis of sister chromatid exchange (SCE) is widely used as an assay for mutagenic carcinogens. There is very little information, however, on whether incorporation of the bromodeoxyuridine (BrdU) necessary for visualization of SCEs affects the sensi