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Induction of self-maintained intoxication in ethanol-dependent rats

✍ Scribed by Marfaing-Jallat, P.; Le Magnen, J.

Book ID
122581898
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
170 KB
Volume
6
Category
Article
ISSN
0376-8716

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πŸ“œ SIMILAR VOLUMES

Temporal relationship of the induction o
Temporal relationship of the induction of tolerance and physical dependence after continuous intoxication with maximum tolerable doses of ethanol in rats
✍ Edward Majchrowicz; Walter A. Hunt πŸ“‚ Article πŸ“… 1976 πŸ› Springer 🌐 English βš– 576 KB

Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity