Physiological correlates of ethanol intoxication, tolerance, and dependence in rat cerebellar purkinje cells
โ Scribed by Joseph Rogers; G.R. Siggins; J.A. Schulman; F.E. Bloom
- Book ID
- 118865958
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 923 KB
- Volume
- 196
- Category
- Article
- ISSN
- 0006-8993
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๐ SIMILAR VOLUMES
Correlations between pairs of spontaneous climbing fiber responses (CFRs) recorded from couples of nearby Purkinje cells (PCs) were studied in immature rats by using cross-correlograms between CFR pairs, and compaired to those in adult animals. Correlations were found as early as day 3. Some days la
Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity