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Induction of protooncogene fos by extracellular signals in primary glial cell cultures

✍ Scribed by D. F. Condorelli; L. Kaczmarek; F. Nicoletti; A. Arcidiacono; P. Dell'Albani; F. Ingrao; G. Magrì; L. Malaguarnera; R. Avola; A. Messina; A. M. Giuffrida Stella

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
595 KB
Volume
23
Category
Article
ISSN
0360-4012

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✦ Synopsis

In the present study various extracellular factors, acting through different second messenger systems, were examined for their capacity to increase the level of c-fos mRNA in primary glial cell cultures. In particular EGF, 12-O-tetradecanoylphorbol 13-acetate, the beta-adrenergic agonist isoproterenol, and the glutamate agonists, ibotenic and quisqualic acid, were studied. All the extracellular stimuli tested induced a rapid and transient increase in c-fos mRNA level in glial cell cultures regardless of the signal transduction pathway and the final effect on cell proliferation.

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