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Induction of physical dependence on pentobarbital by new infusion method in the rat

โœ Scribed by Suzuki, Tsutomu; Otani, Kokichi; Koike, Yoko; Yoshii, Toshio; Yanaura, Saizo


Book ID
122459778
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
745 KB
Volume
13
Category
Article
ISSN
0278-5846

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Induction of physical dependence in rats
โœ Yoshihiko Koga ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Springer ๐ŸŒ English โš– 370 KB

Rats were intermittently medicated at one hour intervals through an implanted intravenous cannula. Physical dependence on morphine and codeine was developed rapidly and it was detectable with the maintenance dose as low as 9.6 mg/kg/day. Physical dependence on pentazocine was also developed with the