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Induction of physical dependence on cyclazocine and pentazocine in the rat

โœ Scribed by Frank J. Laska; Max R. Fennessy


Book ID
118322671
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
674 KB
Volume
48
Category
Article
ISSN
0014-2999

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Induction of physical dependence in rats
โœ Yoshihiko Koga ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Springer ๐ŸŒ English โš– 370 KB

Rats were intermittently medicated at one hour intervals through an implanted intravenous cannula. Physical dependence on morphine and codeine was developed rapidly and it was detectable with the maintenance dose as low as 9.6 mg/kg/day. Physical dependence on pentazocine was also developed with the