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Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites

✍ Scribed by S Kapila; Y Xie; W Wang


Book ID
111274435
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
284 KB
Volume
12
Category
Article
ISSN
1601-6335

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Collagenase-1 (matrix metalloproteinase-1 (MMP-1)) degrades the extracellular matrix and enhances the invasive phenotype of tumor cells. v-src activated MMP-1 transcription through a series of elements in the proximal promoter, including the E2BP (nt-172), polyoma virus enhancer A3 (PEA3) (nt -94),