Induction of megakaryocyte colonies with platelet formation in vitro
โ Scribed by McLEOD, D. L.; SHREEVE, M. M.; AXELRAD, A. A.
- Book ID
- 109699493
- Publisher
- Nature Publishing Group
- Year
- 1976
- Tongue
- English
- Weight
- 560 KB
- Volume
- 261
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/261492a0
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract We have analysed the contribution to megakaryocyte colony formation in methylcellulose made by human plasma, serum, media conditioned by phytohemagglutinin (PHA) stimulated leukocytes (PHAโLCM), erythropoietin (EPO) preparations, and platelets. The culture system was used as a bioassay
The release of platelets into the circulation is preceded by considerable morphologic change of the parent megakaryocyte. The cell extends cytoplasmic processes into the venous sinusoids, which develop constrictions at intervals, revealing putative platelets. The pattern of cytoskeletal distribution