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Induction of insulin resistance by phosphatidylinositol-3-kinase inhibitor in porcine granulosa cells

✍ Scribed by Miaoe Yan; Jing Wang; Xiaoke Wu; Lihui Hou; Haixue Kuang; Yongyan Wang


Book ID
116475322
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
199 KB
Volume
92
Category
Article
ISSN
1556-5653

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In order to study the role of phosphatidylinositol-3-kinase (PI3K), PKB, FRAP, S6 kinase, and MAP kinase in insulin-stimulated glycogen synthesis, we used a specific inhibitor of PI3K, LY294002, the immunosuppressant inhibitor of FRAP, rapamycin, and the inhibitor of MAPK kinase (MEK)/MAPK, PD98059,