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Induction of Apoptosis in Luteinized Granulosa Cells by the MAP Kinase Kinase (MEK) Inhibitor PD98059

✍ Scribed by Rush H. Oliver; Shah M. Khan; Benjamin S. Leung; John Yeh


Book ID
115584400
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
226 KB
Volume
263
Category
Article
ISSN
0006-291X

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We are interested in studying the possibility of modulating prostatic cell growth by manipulating apoptosis. Here we show that 1 pM staurosporine (STS) induces a human androgen-independent prostatic tumor cell line, DU145, to undergo dramatic changes in morphology and results in programmed cell deat