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Induction of insulin receptor expression of human leukemic cells by 1α,25 dihydroxyvitamin D3

✍ Scribed by Thomas J. Chaplinski; Thomas E. Bennett


Book ID
113238886
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
380 KB
Volume
11
Category
Article
ISSN
0145-2126

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## Abstract Treatment with 10^−8^ m 1,25‐dihydroxyvitamin D~3~ for 24 h causes transcriptional activation of the human insulin receptor gene in U‐937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinosito