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Induction of genetic instability by gain-of-function p53 cancer mutants

✍ Scribed by Xu, Y


Book ID
110073000
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
174 KB
Volume
27
Category
Article
ISSN
0950-9232

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## Abstract Cancer might result from both the aberrant activation of genes, whose physiological tuning is essential for the life of a normal cell, and the inactivation of tumor suppressor genes, whose main job is to preserve the integrity of cell genome. Among the latter, p53 is considered a key tu