𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Induction of “General Control” and thermotolerance in cdc mutants of Saccharomyces cerevisiae

✍ Scribed by Messenguy, Francine ;Scherens, Bart

Publisher
Springer
Year
1990
Tongue
English
Weight
742 KB
Volume
224
Category
Article
ISSN
0026-8925

No coin nor oath required. For personal study only.

✦ Synopsis

In Saccharomyces cerevisiae starvation for a single amino acid activates the transcription of a set of genes belonging to different amino acid biosynthetic pathways (General Control, GC). We show that mutants affected in GC regulation are also affected in their response to thermal stress. Moreover, growth conditions that are known to induce heat shock proteins induce the GC response. However, unlike heat shock proteins, the transcriptional activator of GC, GCN4, is not induced after a short exposure to heat, and in gcn mutant strains induction of heat resistance is normal.

📜 SIMILAR VOLUMES

Decreased UV mutagenesis in cdc8, a DNA
Decreased UV mutagenesis in cdc8, a DNA replication mutant of Saccharomyces cerevisiae
✍ Prakash, Louise ;Hinkle, David ;Prakash, Satya 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 816 KB

A DNA replication mutant of yeast, cdc8, was found to decrease UV-induced reversion of lys2-1, arg4-17, tyr1 and ura1. This effect was observed with all three alleles of cdc8 tested. Survival curves obtained following UV irradiation in cdc8 rad double mutants show that cdc8 is epistatic to rad6, as

Transformation and recombination in rad
Transformation and recombination in rad mutants of Saccharomyces cerevisiae
✍ Simon, John R. ;Moore, Peter D. 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 908 KB

Disruption/deletion mutations in genes of the RAD52 epistasis group of Saccharomyces cerevisiae were examined for their effects on recombination between single- and double-stranded circular DNA substrates and chromosomal genes in a transformation assay. In rad50 mutants there was a small reduction i