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Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma

✍ Scribed by Penny E. Lovat; Serafina Oliverio; Marco Corazzari; Marco Ranalli; Andy D.J. Pearson; Gerry Melino; Mauro Piacentini; Christopher P.F. Redfern

Book ID
117467749
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
225 KB
Volume
197
Category
Article
ISSN
0304-3835

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## Abstract The mechanisms of fenretinide‐induced cell death of neuroblastoma cells are complex, involving signaling pathways mediated by free radicals or reactive oxygen species (ROS). The aim of this study was to identify mechanisms generating ROS and apoptosis of neuroblastoma cells in response