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Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma

✍ Scribed by Gilda Raguénez; Annick Mühlethaler-Mottet; Roland Meier; Caroline Duros; Jean Bénard; Nicole Gross

Book ID: 115011831
Publisher: BioMed Central
Year: 2009
Tongue: English
Weight: 738 KB
Volume: 9
Category: Article
ISSN: 1471-2407
DOI: 10.1186/1471-2407-9-97

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## Abstract Fenretinide, which mediates apoptosis in neuroblastoma cells, is being considered as a novel therapeutic for neuroblastoma. The cytotoxic mechanisms of fenretinide, however, have not been fully elucidated. Sustained‐activation of JNK and p38 MAPK signaling has been shown recently to hav