Induction of erythroid leukaemia by Harvey and Kirsten sarcoma viruses
โ Scribed by SCHER, CHARLES D.; SCOLNICK, EDWARD M.; SIEGLER, RICHARD
- Book ID
- 109695970
- Publisher
- Nature Publishing Group
- Year
- 1975
- Tongue
- English
- Weight
- 240 KB
- Volume
- 256
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/256225a0
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## Abstract No focusโforming virus was produced after exposure of stationary mouse embryo cell cultures (achieved by removal of serum) to the marine sarcoma virus (Harvey) complex. Addition of serum to these infected stationary cultures resulted in MSV (Harvey) production following cell division. C
As reported previously (Namba ef a/., 1985), normal human fibroblasts were transformed by %o gammaray irradiation into immortal cells with abnormal karyotypes. These transformed cells (KMST-6), however, showed a low cloning efficiency in soft agar and no transplantability. However, upon treatment wi