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Induction of ERBB2 nuclear transport after radiation in breast cancer cells

✍ Scribed by Bo Luo; Shiying Yu; Liang Zhuang; Shu Xia; Zhen Zhao; Lei Rong

Book ID
107405945
Publisher
Springer-Verlag
Year
2009
Tongue
Chinese
Weight
419 KB
Volume
29
Category
Article
ISSN
0510-9752

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## Abstract Receptor tyrosine kinase activity is essential for erbB2 (HER2/__neu__) promotion of breast carcinogenesis, metastasis and therapeutic resistance. erbB2 kinase can be activated by dimerization with another erbB receptor, most of which bind ligands. Of these, the erbB2/erbB3 heterodimer