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Molecular and functional characteristics of erbB2 in normal and cancer breast cells

✍ Scribed by Stefania Tommasi; Vita Fedele; Rosanna Lacalamita; Antonella Crapolicchio; Elda Perlino; Antonia Bellizzi; Angelo Paradiso


Book ID
116333018
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
216 KB
Volume
209
Category
Article
ISSN
0304-3835

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## Abstract Receptor tyrosine kinase activity is essential for erbB2 (HER2/__neu__) promotion of breast carcinogenesis, metastasis and therapeutic resistance. erbB2 kinase can be activated by dimerization with another erbB receptor, most of which bind ligands. Of these, the erbB2/erbB3 heterodimer