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Induction of DT-diaphorase by doxorubicin and combination therapy with mitomycin C in vitro

โœ Scribed by Asher Begleiter; Marsha K. Leith


Book ID
115784394
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
653 KB
Volume
50
Category
Article
ISSN
0006-2952

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Relevance of DT-diaphorase activity to m
โœ Masahiko Nishiyama; Shuji Saeki; Kenjiro Aogi; Naoki Hirabayashi; Tetsuya Toge ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 510 KB

Using 4 human cancer cell lines, 4 tumors xenografted into nude mice, and I I fresh tumor specimens removed at surgery, we investigated the relevance of NAD(P)H:quinone oxidoreductase (DT-diaphorase, DTD) activity (nmoles/min/mg protein) to mitomycin C (MMC)-induced cytotoxicity. In culture cell lin