INDUCTION OF DNA STRAND BREAKS IN NORMAL HUMAN FIBROBLASTS EXPOSED TO MONOCHROMATIC ULTRAVIOLET AND VISIBLE WAVELENGTHS IN THE 240–546 nm RANGE

Induction of DNA strand breaks and DNA—p

Induction of DNA strand breaks and DNA—protein cross-links in normal human skin fibroblasts following exposure to 254 nm UV radiation

✍ Li-Wen Lai; Barry S. Rosenstein 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 673 KB

Levels of DNA strand breaks and DNA-protein cross-links (DPCs) were measured using the alkaline elution assay in normal human skin fibroblasts irradiated with 0-200 J m-2 of 254 nm UV radiation and incubated for 0-24 h. On incubation, the yields of both single-strand breaks (SSBs) and DPCs increased