Induction of DNA damage response by the supravital probes of nucleic acids
β Scribed by Hong Zhao; Frank Traganos; Jurek Dobrucki; Donald Wlodkowic; Zbigniew Darzynkiewicz
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 694 KB
- Volume
- 75A
- Category
- Article
- ISSN
- 0196-4763
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π SIMILAR VOLUMES
Polyamide or peptide nucleic acids (PNAs), first described in 1991, [1] are DNA analogues based entirely on an achiral polyamide backbone (Scheme 1). The PNAs undergo sequence-specific and efficient Watson Β± Crick base pairing with Scheme 1. Sections of the chemical structures of deoxyribonucleic ac
## Abstract Peptide nucleic acids (PNAs) containing an insert of three chiral monomers based on Dβlysine (βchiral boxβ) were synthesized and used as probes in Biospecific Interaction Analysis (BIA) for the recognition of DNA containing the W1282X point mutation of the cystic fibrosis gene. Hybridiz