## Abstract Unscheduled DNA synthesis has been measured in human fibroblasts under conditons of reduced rates of conversion of NAD to poly(ADPβribose). Cells heterozygous for the xeroderma pigmentosum genotype showed normal rates of UV induced unscheduled DNA synthesis under conditions in which the
Induction of DNA damage by urethane in mouse testes: DNA binding and unscheduled DNA synthesis
β Scribed by Rene E. Sotomayor; Gary A. Sega; Fred Kadlubar
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 658 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0893-6692
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The effect of route of administration on induction of unscheduled DNA synthesis (UDS) in mouse germ cells in vivo was studied using two germ cell mutagens, methyl methanesulfonate (MMS) and triethylenemelamine (TEM). The chemicals were administered to male mice (C3Hf X 101)Fl by IP injection or gava
An autoradiographic procedure was used to measure unscheduled DNA synthesis (UDS, DNA repair synthesis) in spermatogonial and postspermatogonial cell stages of mice after treatment with two doses of N-ethyl-N-nitrosourea (ENU) and N-methyl-N-nitrosourea (MNU). Significant levels of UDS were measured