β Scribed by Dr. Purushottam Kale; Ranjini Kale
No coin nor oath required. For personal study only.
Two carcinogens, ethylene dibromide and benzene, were used to induce delayed (germinal mcsaic) sex-linked recessive lethal mutations in spermatozoa and spermatids of adult Drosophila males.
were scored in absence of conventional (in F2) mutations. A large proportion of nonlethal F2 cultures carried delayed mutations, so much so that, in some cultures, all F2 females were carriers of mutations. The mechanism through which single strand dam-age to treated X chromosomes can result in such delayed lethals is discussed. These observations indicate that the delayed mutation test should be used for testing the mutagenicity of environmental compounds, especially carcinogens, which tested negative in the conventional sex-linked recessive lethal mutation test. The data will support the relationship between mutagenesis and carcinogenesis and, also will further enhance the sensitivity of the Drosophila mutation assay.
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In this work, we studied the excess volume of solutions of low molecular weight poly-(ethylene glycol)s (200, 400, and 600) in water and in benzene. We noted that there is a higher contraction of the volume for water solutions in all compositions. Solutions of these polymers in benzene also undergo
## Abstract As a nuclear phosphoprotein, protoβoncogene protein DEK is capable to changing chromatin structure. DEK was recently identified as an inhibitor of histone acetylation mediated by p300 and PCAF and to facilitate transcriptional repression. To elucidate the biological functions of DEK in