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Induction of cytochrome P450 2B1 by pyrethroids in primary rat hepatocyte cultures

โœ Scribed by Heder, Anne F; Hirsch-Ernst, Karen I; Bauer, Daniel; Kahl, Georg F; Desel, Herbert


Book ID
122470118
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
516 KB
Volume
62
Category
Article
ISSN
0006-2952

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In this investigation, we examined the effects of insulin on gene induction responsiveness in primary rat hepatocytes. Cells were cultured for 72 hours either in the absence or presence of 1 lM insulin and then exposed to increasing concentrations of phenobarbital (PB; 0.01-3.5 mM). Culturing in the