## Abstract ## Background Human CD4^+^CD25^+^FOXP3^+^ natural regulatory Tโcells (nTreg) have a great therapeutic potential for the induction of tolerance in alloโtransplanted patients or for the control of severe autoโimmune diseases. However, clinicalโgrade production of nTreg remains difficult
Induction of chemosensitivity in nasopharyngeal carcinoma cells using a human papillomavirus regulatory sequence and the thymidine kinase gene
โ Scribed by Kai-Ping N. Chow; Hsi-Chi Lu; Huar-Fen Chou; Hao-Ping Liu; Shie-Liang Hsieh; Yu-Sun Chang; Kong-Bung Choo
- Book ID
- 105516501
- Publisher
- BioMed Central
- Year
- 2002
- Tongue
- English
- Weight
- 871 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1021-7770
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We have analyzed the ability of a recombinant replication-defective adenovirus to transfer the thymidine kinase gene of herpes simplex virus (HSV-tk) into hepatocellular carcinoma (HCC) cells to confer sensitivity to ganciclovir. Three HCC cell lines (Hep3B, PLC/PRF/5, and HepG2) were efficiently in
## Abstract This Response refers to JGM 1286, which was published in The Journal of Gene Medicine **11:2**. Please follow the link below to view the Letter to the Editor. Letter to the Editor
## Abstract We previously showed that gap junction intercellular communication mediates the bystander effect in anticancer gene therapy with the herpes simplex virus thymidine kinase (HSVโtk) and ganciclovir. Because most cancer cell lines have lost their ability to communicate through gap junction