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Induction of CD4+25+FoxP3+ Regulatory T cells from naïve CD4+25-FoxP3- T cells in vivo by pancreas adenocarcinoma

✍ Scribed by T.A. Moo-Young; J.W. Larson; P.S. Goedegebuure; W.G. Hawkins; T.J. Eberlein; D.C. Linehan

Book ID
116702119
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
49 KB
Volume
130
Category
Article
ISSN
0022-4804

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## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a