Induction of c- and 1,25-dihydroxy-vitamin D receptor mRNA expression
✍ Scribed by PAATERO, G; TRYDAL, T; LILLEHAUG, J; KARLSTEDT, K
- Book ID
- 122173137
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 136 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0309-1651
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1a,25-dihydroxy vitamin D3 has a major role in the regulation of the bone metabolism as it promotes the expression of key bone-related proteins in osteoblastic cells. In recent years it has become increasingly evident that in addition to its well-established genomic actions, 1a,25-dihydroxy vitamin
## Abstract Binding of 1α,25‐dihydroxy vitamin D~3~ to the C‐terminal ligand‐binding domain (LBD) of its receptor (VDR) induces a conformational change that enables interaction of VDR with transcriptional coactivators such as members of the p160/SRC family or the DRIP (vitamin D receptor‐interactin