Induction of Bone Morphogenetic Protein-2 by Interleukin-1 in Human Fibroblasts
β Scribed by Martin J. Fowler Jr.; Michael S. Neff; Ruth C. Borghaei; Elizabeth A. Pease; Eugene Mochan; Ruth D. Thornton
- Book ID
- 115582406
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 152 KB
- Volume
- 248
- Category
- Article
- ISSN
- 0006-291X
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We have examined the effects of BMP-2 on the expression of bone matrix proteins in both human bone marrow stromal cells (HBMSC) and human osteoblasts (HOB) and their proliferation and mineralization. Both HBMSC and HOB express BMP-2/-4 type I and type II receptors. Treatment of these two cell types
## Abstract ## Background Bone morphogenetic proteinβ2 (BMPβ2) is an osteoinductive protein and is considered useful for the treatment of skeletal disorders. Previous studies using BMPβ2 in clinical applications have encountered difficulties, including the lack of an efficient, safe, inexpensive a