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Induction of apoptosis via mitogen-activated protein kinase pathway by a K vitamin analog in rat hepatocytes

✍ Scribed by Ziqiu Wang; Yuji Nishikawa; Meifang Wang; Brian I Carr


Book ID
119526744
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
305 KB
Volume
36
Category
Article
ISSN
0168-8278

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Compound 5 (Cpd 5), a synthetic K vitamin analogue, or 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone, is a potent inhibitor of epidermal growth factor (EGF)-induced rat hepatocyte DNA synthesis and induces EGF receptor (EGFR) tyrosine phosphorylation. To understand the cellular responses to Cpd