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Induction of apoptosis in MDR1 expressing cells by daunorubicin with combinations of suboptimal concentrations of P-glycoprotein modulators

✍ Scribed by Adorjan Aszalos; Andrea Ladányi; József Bocsi; Béla Szende


Book ID
117466919
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
293 KB
Volume
167
Category
Article
ISSN
0304-3835

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Mammalian liver exhibits expression of members of the family of multidrug resistance (mdr) transporters (P-glycoproteins). P-glycoprotein isoforms encoded by mdr1 genes participate in extrusion of an array of xenobiotics into the bile. Induction of mdr1b mRNA expression has been shown to occur in ra