Induction of Apoptosis in HeLa Cells by 3β-Hydroxyurs-12-en-27-oic Acid
✍ Scribed by Quan-Fang Zheng; Hong-Xiang Sun; Qiao-Jun He; Yi-Ping Ye
- Book ID
- 102776003
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 892 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1612-1872
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3b-Hydroxyolean-12-en-27-oic acid (1), a biologically active, pentacyclic triterpenoid isolated from the rhizomes of Astilbe chinensis, was found to be considerably more cytotoxic toward human colorectal carcinoma (COLO-205) and human cervical squamous carcinoma (HeLa) cells than its congener oleano
The title compound, C 30 H 48 O 3 ÁCH 4 O, is a cytotoxic and apoptosis-inducing triterpenoid which was isolated from the rhizome of Astilbe chinensis. The molecule is composed of ®ve six-membered rings. The cyclohexene ring adopts a slightly distorted half-chair conformation and the cyclohexane rin