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3β-Hydro­xy­olean-12-en-27-oic acid methanol solvate: a cytotoxic and apoptosis-inducing triterpenoid from the rhizome of Astilbe chinensis

✍ Scribed by Sun, Hong-Xiang ;Ye, Yi-Ping ;Wang, Kui-Wu ;Pan, Yuan-Jiang

Publisher
International Union of Crystallography
Year
2003
Tongue
English
Weight
219 KB
Volume
59
Category
Article
ISSN
1600-5368

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✦ Synopsis

The title compound, C 30 H 48 O 3 ÁCH 4 O, is a cytotoxic and apoptosis-inducing triterpenoid which was isolated from the rhizome of Astilbe chinensis. The molecule is composed of ®ve six-membered rings. The cyclohexene ring adopts a slightly distorted half-chair conformation and the cyclohexane rings adopt chair conformations. The hydroxy and carboxy groups both serve simultaneously as hydrogen-bond donors and acceptors, forming molecular chains.

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3β-Hydroxyolean-12-en-27-oic Acid: A Cyt
3β-Hydroxyolean-12-en-27-oic Acid: A Cytotoxic, Apoptosis-Inducing Natural Drug against COLO-205 Cancer Cells
✍ Jue Tu; Hong-Xiang Sun; Yi-Ping Ye 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 306 KB

3b-Hydroxyolean-12-en-27-oic acid (1), a biologically active, pentacyclic triterpenoid isolated from the rhizomes of Astilbe chinensis, was found to be considerably more cytotoxic toward human colorectal carcinoma (COLO-205) and human cervical squamous carcinoma (HeLa) cells than its congener oleano