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Induction of apoptosis by 1,25-dihydroxyvitamin D3 in MCF-7 Vitamin D3-resistant variant can be sensitized by TPA

✍ Scribed by Carmen J. Narvaez; Belinda M. Byrne; Saara Romu; Meggan Valrance; JoEllen Welsh


Book ID
117668475
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
395 KB
Volume
84
Category
Article
ISSN
0960-0760

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## Abstract 1Ξ±,25‐Dihydroxyvitamin D~3~ [1Ξ±,25(OH)~2~D~3~], the hormonally active form of vitamin D~3~, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1Ξ±,25(OH)~2~D~3~ acts through two different mechanisms. In addition to regulating gene tr