Induction of apoptosis by 1,25-dihydroxyvitamin D3 in MCF-7 Vitamin D3-resistant variant can be sensitized by TPA
β Scribed by Carmen J. Narvaez; Belinda M. Byrne; Saara Romu; Meggan Valrance; JoEllen Welsh
- Book ID
- 117668475
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 395 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0960-0760
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The biologically active form of vitamin D 3 , the nuclear hormone 1a,25-dihydroxyvitamin D 3 (VD), is an important regulator of cellular growth, differentiation, and death. The hormone mediates its action through the activation of the transcription factor VDR, which is a member of the superfamily of
## Abstract 1Ξ±,25βDihydroxyvitamin D~3~ [1Ξ±,25(OH)~2~D~3~], the hormonally active form of vitamin D~3~, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1Ξ±,25(OH)~2~D~3~ acts through two different mechanisms. In addition to regulating gene tr