Treatment of HL-60 cells with micromolar concentrations of N 6 -benzyladenosine (N 6 -benzylaminopurine riboside [BAPR]) led to the occurrence of apoptosis in a concentration-dependent manner. Incubation period as short as 2 h in the presence of BAPR was sufficient for triggering irreversible change
Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells
β Scribed by D. P. Cioca; K. Kitano
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 381 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Neutral endopeptidase (NEP/CD10) is a cell surface zinc metalloprotease cleaving peptide bounds on the amino terminus of hydrophobic amino acids and inactivating multiple physiologically active peptides. Loss or decrease in NEP/CD10 expression have been reported in many types of maligna
We previously reported that all-trans retinoic acid (RA) and fenretinide (4HPR) suppress HL-60 leukemia cell growth and cause partial cell arrest in the G 1 -to-S phase. Moreover, 4HPR but not RA induces apoptosis in HL-60 cells. To investigate further the observed biological effects, cyclin D1 and