Treatment of HL-60 cells with micromolar concentrations of N 6 -benzyladenosine (N 6 -benzylaminopurine riboside [BAPR]) led to the occurrence of apoptosis in a concentration-dependent manner. Incubation period as short as 2 h in the presence of BAPR was sufficient for triggering irreversible change
Bacterial cytotoxicity and induction of apoptosis in promyelocytic (Line HL-60) cells by novel organotellurium compounds
β Scribed by Brian L. Sailer; Tarl Prow; Sarah Dickerson; John Watson; Nathan Liles; Shiv J. Patel; Verena Van Fleet-Stalder; Thomas G. Chasteen
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 142 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0730-7268
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## Abstract Various compounds active in promoting in vitro differentiation of certain murine leukemia cell lines (Friend erythroleukemia cells and mouse myeloid leukemia cells) were tested for their capacity to induce differentiation of HLβ60 cells, a human promyelocytic leukemia cell line capable
We previously reported that all-trans retinoic acid (RA) and fenretinide (4HPR) suppress HL-60 leukemia cell growth and cause partial cell arrest in the G 1 -to-S phase. Moreover, 4HPR but not RA induces apoptosis in HL-60 cells. To investigate further the observed biological effects, cyclin D1 and