Induction of antitumor immunity by indomethacin
โ Scribed by Shoshana Morecki; Elena Yacovlev; Yael Gelfand; Victoria Trembovler; Esther Shohami; Shimon Slavin
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 152 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0340-7004
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๐ SIMILAR VOLUMES
CTLs specific for tumor antigens play a major role in immunity against cancer. Improved binding affinity of putative TAA peptides could enhance the in vivo immunogenicity of these self-altered self-tumor antigens. We examined here the efficacy of tumor vaccines composed of an altered peptide ligand
Indomethacin, an inhibitor of cyclo-oxygenase given orally, reduced the tumorigenicity of cancer cells in a non-immunogenic murine model of mammary adenocarcinoma (4T1). In the presence of indomethacin, a dose-dependent immune protection could be induced most effectively by immunizing mice with 1 to