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Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA

✍ Scribed by Michiels, A; Breckpot, K; Corthals, J; Tuyaerts, S; Bonehill, A; Heirman, C; Thielemans, K; Aerts, J L

Book ID
110039803
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
327 KB
Volume
13
Category
Article
ISSN
0969-7128

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## BACKGROUND. Most strategies in cancer immunotherapy are aimed at the induction of a strong cellular immune response against the tumor. Particularly, CD8 + T lymphocytes have been proven in multiple animal models to be critical for the eradication of solid tumors. METHODS. We used a population o