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Induction of alkaline phosphatase activity in hela cells: Inhibition by xanthine derivatives and thermostability studies

✍ Scribed by Walker Wharton; Barry Goz

Book ID
115774615
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
639 KB
Volume
28
Category
Article
ISSN
0006-2952

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πŸ“œ SIMILAR VOLUMES

The inhibition by xanthine phosphodieste
The inhibition by xanthine phosphodiesterase inhibitors of the induction of alkaline phosphatase activity in HeLa cells: Relationship of enzyme activity to cyclic AMP concentrations
✍ Walker Wharton; Barry Goz πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 681 KB

## Abstract The three xanthine derivatives, caffeine, theophylline and 3‐isobutyl‐1‐methyl‐xanthine (IBMX) produced dose‐dependent increases in cyclic AMP concentrations in HeLa cells after long term treatment. Only IBMX produced increases over the first 60 minutes, with a peak of approximately 5‐f

The requirement of DNA synthesis for the
The requirement of DNA synthesis for the induction of alkaline phosphatase by bromodeoxyuridine in a derivative of the HeLa cell line
✍ John Morrow; Douglas M. Stocco; Joe A. Fralick πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 722 KB

## Abstract Non‐lethal concentrations of bromodeoxyuridine induce a 2‐ to 5‐fold increase in the specific activity of alkaline phosphatase in HeLa subclone, S3G. Experiments employing 10‐hour pulses of BRdU showed that 48 hours were required before induction commenced, and that maximal induction wa