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Induction of AKT phosphorylation and FGFR expression in human endothelial cells by anti-HLA antibodies is locus and titer dependent

✍ Scribed by Xiaohai Zhang; Peter T. Jindra; Yiping Jin; Frans Claas; Arend Mulder; Elaine F. Reed


Book ID
116530931
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
31 KB
Volume
66
Category
Article
ISSN
0198-8859

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## Objective: To assess the ability of anti-proteinase 3 (anti-pr3) classic antineutrophil cytoplasmic antibodies (canca) to stimulate endothelial expression of tissue factor (tf), which is the main initiator of the coagulation cascade that can lead to endothelial injury and thrombosis in patients