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Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti–endothelial cell antibodies

✍ Scribed by S. Sohail Ahmed; Filemon K. Tan; Frank C. Arnett; Li Jin; Yong-Jian Geng


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
906 KB
Volume
54
Category
Article
ISSN
0004-3591

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## Objective: To assess the ability of anti-proteinase 3 (anti-pr3) classic antineutrophil cytoplasmic antibodies (canca) to stimulate endothelial expression of tissue factor (tf), which is the main initiator of the coagulation cascade that can lead to endothelial injury and thrombosis in patients