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Induction of Aberrant Crypt Foci in the Large Intestine of F344 Rats by Oral Administration of 2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine

✍ Scribed by Takahashi, Satoru ;Ogawa, Kumiko ;Ohshima, Hiroshi ;Esumi, Hiroyasu ;Ito, Nobuyuki ;Sugimura, Takashi


Book ID
108579261
Publisher
Wiley (Blackwell Publishing)
Year
1991
Tongue
English
Weight
220 KB
Volume
82
Category
Article
ISSN
0910-5050

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## Abstract 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP), an abundant food‐derived heterocyclic amine (HCA), has attracted particular attention as a human colon carcinogen. Humans are in fact exposed to continuous low doses of HCAs during lifetime. Therefore, we focused on rat large i