Induction of 3T3 cell division at the monolayer stage: Early changes in macromolecular processes
β Scribed by K.D. Noonan; M.M. Burger
- Book ID
- 118876227
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- English
- Weight
- 798 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0014-4827
No coin nor oath required. For personal study only.
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Through a receptor-mediated process glucocorticosteroids block cell division by 20-45 hours in SV40-transformed 3T3 (SV313) mouse fibroblasts growing in a low calf serum (0.30% v/v) medium containing biotin. However, the rate of D N A synthesis, determined at various times after dexamethasone additi
## Abstract Swiss 3T3 cells express receptors for both the polypeptide epidermal growth factor (EGF) and the tetradecapeptide bombesin and respond mitogenically to these substances. These cells thus provide a system to analyze potential signal transduction pathways involved in mitogenic stimulation