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Induction chemotherapy for organ preservation in advanced laryngeal cancer: Is there a role?

✍ Scribed by Dr. Gregory T. Wolf; Waun Ki Hong

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
523 KB
Volume
17
Category
Article
ISSN
1043-3074

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✦ Synopsis

During the past 15 years, the accumulated experience in the use of induction or initial chemotherapy in patients with head and neck squamous cell carcinoma has led to new treatment strategies as alternatives to surgery in patients with advanced, previously untreated laryngeal cancer. These have been termed organ preservation approaches and, in general, have consisted of several cycles of initial chemotherapy with selection of responding patients to receive radiation therapy and nonresponding patients to undergo surgery. The role of such treatment strategies in the routine management of head and neck cancer patients remains unclear and controversial. The large number of clinical trails of induction chemotherapy that have been completed over the past 15 years have demonstrated both the feasibility and the high tumor regression rates associated with induction chemotherapy.'-* None of these studies, however, has shown any improve-From the

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