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Chemotherapy alone for organ preservation in advanced laryngeal cancer

✍ Scribed by Vasu Divi; Francis P. Worden; Mark E. Prince; Avraham Eisbruch; Julia S. Lee; Carol R. Bradford; Douglas B. Chepeha; Theodoros N. Teknos; Norman D. Hogikyan; Jeffrey S. Moyer; Christina I. Tsien; Susan G. Urba; Gregory T. Wolf

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
504 KB
Volume
32
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. For patients with advanced laryngeal cancer, a trial was designed to determine if chemotherapy alone, in patients achieving a complete histologic complete response after a single neoadjuvant cycle, was an effective treatment with less morbidity than concurrent chemoradiotherapy.

Methods. Thirty-two patients with advanced laryngeal or hypopharyngeal cancer received 1 cycle of induction chemotherapy, and subsequent treatment was decided based on response.

Results. A histologic complete response was achieved in 4 patients and were treated with chemotherapy alone. All 4 patients' cancer relapsed in the neck and required surgery and postoperative radiotherapy (RT). Twenty-five patients were treated with concomitant chemoradiation. Three patients were treated with surgery. Overall survival and disease-specific survival at 3 years were 68% and 78%, respectively.

Conclusion. Chemotherapy alone is not feasible for longterm control of regional disease in patients with advanced laryngeal cancer even when they achieve a histologic complete response at the primary site. V

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