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Inducible Nitric Oxide Synthase Mediates Prostaglandin H2 Synthase Nitration and Suppresses Eicosanoid Production

✍ Scribed by Ruba S. Deeb; Hao Shen; Caryn Gamss; Tatyana Gavrilova; Barbara D. Summers; Rosemary Kraemer; Gang Hao; Steven S. Gross; Muriel Lainé; Nobuyo Maeda; David P. Hajjar; Rita K. Upmacis

Book ID
117970450
Publisher
American Society for Investigative Pathology
Year
2006
Tongue
English
Weight
568 KB
Volume
168
Category
Article
ISSN
0002-9440

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It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot and in situ hybridization analysis and a 131-kDa