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Induced Axial Chirality in the Biphenyl Core of the Proatropoisomeric, Cα-Tetrasubstituted α-Amino Acid Residue Bip in Peptides

✍ Scribed by Jean-Paul Mazaleyrat; Karen Wright; Anne Gaucher; Nathalie Toulemonde; Laurence Dutot; Michel Wakselman; Quirinus B. Broxterman; Bernard Kaptein; Simona Oancea; Cristina Peggion; Marco Crisma; Fernando Formaggio; Claudio Toniolo


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
218 KB
Volume
11
Category
Article
ISSN
0947-6539

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✍ Cristina Peggion; Fernando Formaggio; Marco Crisma; Claudio Toniolo; Bernard Kap 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 1 views

The lipophilic, chiral, C h -methylated h-amino acid L-(h Me)Aoc (2-methyl-2-amino-octanoic acid) was prepared using a chemo-enzymatic approach. Two series of terminally protected model peptides, from dimer through to hexamer, containing L-(h Me)Aoc in combination with either Gly or Aib, were synthe