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Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase

✍ Scribed by KANTOR, HARVEY S.; HAMPTON, MICHAEL


Book ID
109711671
Publisher
Nature Publishing Group
Year
1978
Tongue
English
Weight
229 KB
Volume
276
Category
Article
ISSN
0028-0836

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Extracts of fasted rat diaphragms, previously treated with or without insulin were assayed for glycogen synthase, protein kinase and cyclic [3H]-AMP binding. Treatment with insulin produced an elevation in the % of glycogen synthase I and a concurrent decrease in cyclic AMP-dependent protein kinase